Endocrine Abstracts

Introduction: The silencing mechanisms of corticotroph tumors (CT) remain unclear. The most feasible hypothesis lies in a post-transcriptional deregulation of the POMC gene, precursor of ACTH. Micro RNAs (miRNAs) are small non-coding RNA molecules involved in the epigenetic regulation of gene expression through their inhibitory action on messenger RNA. miRNAs capable of inhibiting the expression of POMC have been described at the level of neurons of the hypot...

Introduction: Silent somatotroph tumors (sST) are a pituitary neuroendocrine tumor subtype with positive immunostaining for growth hormone (GH) but without the presence of acromegaly. Unlike silent corticotroph tumors, there is little information in the literature on sST. The aim of the present study was to study the demographic, clinical and molecular characteristics in a series of ST in order to compare sST and functioning ST (fST).Methods: We have stu...

Introduction: The last World Health Organization (WHO) 2016 classification of Pituitary Tumours recommends the determination of transcription factors. During the last few years, silent variants of the main pituitary tumours (PTs) have been described. The mechanisms of silencing of these tumors are still unknown. POU1F1 (Pit1) encodes a member of the POU family of transcription factors that has a relevant role in the differentiation, proliferation and survival of three...

Introduction: Salivary cortisol measurement is a non-invasive and easy test to carry out. It is painless and does not cause stress.Aim: The aim of the present study was to evaluate the correlation between salivary cortisol (SaC) and serum cortisol (SeC) after 1 mg Dexamethasone (DXM) overnight and their diagnostic utility as screening test of Cushing’s syndrome (CS).Methods: We performed a prospective study in 92 patients with...

Introduction: Recently we have demonstrated the contribution of the quantification of expression of adenohypophyseal hormone genes in the identification of the different Pituitary Neuroendocrine Tumor (PitNET) subtypes according to the 2004 WHO criteria.Aim: The aim of the present study was to evaluate the contribution of the quantification of expression of pituitary transcription factor genes to the identification of PitNETs according to 2017 WHO criter...

Introduction: Pituitary Neuroendocrine Tumor (PitNET) subtypes present functioning and silent variants but the silencing mechanisms are still unknown. One of the possible hypotheses could be a decrease in the expression of the specific adenohypophyseal hormone genes. The aim of the present study was to analyze the expression of adenohypophyseal hormone genes in a series of PitNETs, in order to evaluate differences between functioning and silent PitNET subtypes, taking into acc...